Linker Phosphoramidites
5'-DBCO-TEG Phosphoramidite
Quick view. 5'-DBCO-TEG Phosphoramidite is a non-nucleosidic linker phosphoramidite identified by CAS 1527468-08-1. CAS 1527468-08-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-DBCO-TEG Phosphoramidite is classified as linker phosphoramidites (Formula C38H53N4O7P; molecular weight 708.84).
5'-DBCO-TEG Phosphoramidite — Reference use: introduction of a 5' DBCO-TEG handle during oligonucleotide synthesis for subsequent azide conjugation by copper-free click chemistry.
For 5'-DBCO-TEG Phosphoramidite, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- DBCO-TEG Phosphoramidite
- DBCO-PEG4 Phosphoramidite
Useful catalog search terms
- CAS 1527468-08-1
- AZZYBGFXRGQDBX-UHFFFAOYSA-N
- PubChem CID 121235601
Physicochemical data
| Linker architecture | DBCO group with a TEG spacer and a 2-cyanoethyl N,N-diisopropylphosphoramidite terminus |
|---|---|
| Phosphorus stereochemistry | Unspecified; no single phosphorus configuration is assigned |
| PubChem CID | 121235601 |
| InChIKey | AZZYBGFXRGQDBX-UHFFFAOYSA-N |
| InChI | InChI=1S/C38H53N4O7P/c1-31(2)42(32(3)4)50(48-22-11-20-39)49-29-28-47-27-26-46-25-24-45-23-21-40-37(43)16-9-10-17-38(44)41-30-35-14-6-5-12-33(35)18-19-34-13-7-8-15-36(34)41/h5-8,12-15,31-32H,9-11,16-17,21-30H2,1-4H3,(H,40,43) |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)CCCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 5'-DBCO-TEG Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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