2'-O-Me Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-3'-O-acetyl-5-iodouridine
Quick view. A protected 2'-O-methyluridine derivative bearing 5'-O-DMTr and 3'-O-acetyl groups with iodine at uracil C5, CAS 1374692-34-8. CAS 1374692-34-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-3'-O-acetyl-5-iodouridine is classified as 2'-o-me nucleosides (Formula C33H33IN2O9; molecular weight 728.53).
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-3'-O-acetyl-5-iodouridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-3'-O-acetyl-5-iodouridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-Acetyl-5'-O-DMT-5-iodo-2'-O-methyluridine
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyluridine 3'-acetate
Useful catalog search terms
- CAS 1374692-34-8
Physicochemical data
| SMILES | CC(=O)O[C@@H]1[C@H](O[C@H]([C@@H]1OC)N2C=C(C(=O)NC2=O)I)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
|---|---|
| Sugar modification | 2'-O-methyl |
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| 3' protection | Acetyl |
| Base substitution | 5-Iodouracil |
| PubChem CID | 91827913 |
| InChIKey | FRHDXHYTYBOQIT-BUVRPPHQSA-N |
| InChI | InChI=1S/C33H33IN2O9/c1-20(37)44-28-27(45-31(29(28)42-4)36-18-26(34)30(38)35-32(36)39)19-43-33(21-8-6-5-7-9-21,22-10-14-24(40-2)15-11-22)23-12-16-25(41-3)17-13-23/h5-18,27-29,31H,19H2,1-4H3,(H,35,38,39)/t27-,28-,29-,31-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-3'-O-acetyl-5-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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