Stereodefined PS / Phosphoramidites
5'-O-DMTr-2'-O-Me-C 3'-(D)-DPSE oxazaphospholidine phosphoramidite
Quick view. 5'-O-DMTr-2'-O-Me-C 3'-(D)-DPSE oxazaphospholidine phosphoramidite is a name-defined 2'-O-methyl C oxazaphospholidine phosphoramidite carrying the D-DPSE auxiliary designation. Exact molecular structure, supplied form, specification, packaging and current availability require technical confirmation. CAS N/A. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Highest development phase | Phase II |
| CAS status | Not published for this exact form |
Product profile
5'-O-DMTr-2'-O-Me-C 3'-(D)-DPSE oxazaphospholidine phosphoramidite is classified as stereodefined ps / phosphoramidites.
5'-O-DMTr-2'-O-Me-C 3'-(D)-DPSE oxazaphospholidine phosphoramidite supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-DMTr-2'-O-Me-C 3'-(D)-DPSE oxazaphospholidine phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Name-declared catalog attributes
These values are transcribed from the approved catalog name and taxonomy. They do not establish CAS, full molecular structure, salt form, stereochemical assignment, assay or supply specification.
| Product family | Oxazaphospholidine phosphoramidite |
|---|---|
| Nucleic-acid platform | 2'-O-methyl |
| Nucleobase notation | C |
| 5'-O protecting group | DMTr |
| Auxiliary type | DPSE |
| Auxiliary designation | D |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-C 3'-(D)-DPSE oxazaphospholidine phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.