Other Phosphoramidites
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite
Quick view. A 5'-O-DMTr, 2'-O-methyluridine derivative bearing a 3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite group, CAS 191786-64-8. CAS 191786-64-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite is classified as other phosphoramidites (Formula C38H48N3O8P; molecular weight 705.79).
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-OMeU-methyl phosphonamidite
Useful catalog search terms
- CAS 191786-64-8
- C38H48N3O8P
- methyl phosphonamidite
- OMQYBRGCCIXKCN-IFQFNZHASA-N
Physicochemical data
| Nucleobase | Uracil |
|---|---|
| 5' protection | O-DMTr |
| 2' substitution | O-Methyl |
| 3'-function | O-(P-methyl-N,N-diisopropylamino)phosphonamidite |
| Stereochemistry | Four assigned sugar stereocenters; phosphorus center unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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