LNA Phosphoramidites
5'-O-DMTr-LNA-5MeU-methyl phosphonamidite
Quick view. A 5'-O-DMTr-protected LNA 5-methyluridine reagent bearing a 3'-O-P-methyl-N,N-diisopropylamino phosphonamidite group. CAS 527699-22-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-LNA-5MeU-methyl phosphonamidite is classified as protected lna 5-methyluridine methyl phosphonamidite (Formula C39H48N3O8P; molecular weight 717.79 g/mol).
5'-O-DMTr-LNA-5MeU-methyl phosphonamidite is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA T Me-amidite
- 5'-O-DMTr-2'-O,4'-C-methylene-5-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino) phosphonamidite
Useful catalog search terms
- 527699-22-5
- KELNLCGGFQBWBS-KCBKHKGWSA-N
Physicochemical data
| IUPAC name | 1-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-(((diisopropylamino)(methyl)phosphaneyl)oxy)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
|---|---|
| InChIKey | KELNLCGGFQBWBS-KCBKHKGWSA-N |
| InChI | InChI=1S/C39H48N3O8P/c1-25(2)42(26(3)4)51(8)50-34-33-36(41-22-27(5)35(43)40-37(41)44)49-38(34,23-47-33)24-48-39(28-12-10-9-11-13-28,29-14-18-31(45-6)19-15-29)30-16-20-32(46-7)21-17-30/h9-22,25-26,33-34,36H,23-24H2,1-8H3,(H,40,43,44)/t33-,34+,36-,38-,51?/m1/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@H]3[C@@H]([C@@](O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(C)N(C(C)C)C(C)C |
| Canonical SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@H]3[C@@H]([C@@](O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(C)N(C(C)C)C(C)C |
| PubChem CID | 101217873 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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