Intermediates
DBCO-Sulfo-NHS Ester Sodium
Quick view. DBCO-Sulfo-NHS Ester Sodium is an amine-reactive click-chemistry intermediate identified by CAS 1400191-52-7. CAS 1400191-52-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DBCO-Sulfo-NHS Ester Sodium is classified as intermediates (Formula C25H21N2NaO8S; molecular weight 532.50).
DBCO-Sulfo-NHS Ester Sodium — Reference use: amine coupling to introduce a DBCO handle for subsequent strain-promoted azide-alkyne cycloaddition research.
For DBCO-Sulfo-NHS Ester Sodium, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- DBCO-sulfo-NHS ester
Useful catalog search terms
- CAS 1400191-52-7
- C25H21N2NaO8S
Physicochemical data
| Functional groups | DBCO and sulfo-NHS ester |
|---|---|
| PubChem CID | 77078153 |
| InChIKey | QXKHPYSXPCJSPR-UHFFFAOYSA-M |
| InChI | InChI=1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1 |
| SMILES | C1C(C(=O)N(C1=O)OC(=O)CCCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42)S(=O)(=O)[O-].[Na+] |
| Canonical SMILES | C1C(C(=O)N(C1=O)OC(=O)CCCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42)S(=O)(=O)[O-].[Na+] |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe DBCO-Sulfo-NHS Ester Sodium or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.