Modified Nucleosides
S-Adenosyl-L-methionine (SAM)
Quick view. S-Adenosyl-L-methionine is an adenosylated sulfonium cofactor used as a methyl-group donor in methyltransferase and biochemical pathway research. CAS 485-80-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
S-Adenosyl-L-methionine (SAM) is classified as adenosylated sulfonium cofactor (Formula C15H23N6O5S+; molecular weight 399.40).
S-Adenosyl-L-methionine (SAM) — SAM is used as a coenzyme and methyl-group donor in studies of methyltransferase-mediated modification of metabolites, DNA, RNA and proteins.
For S-Adenosyl-L-methionine (SAM), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- S-Adenosylmethionine
- SAM
- SAMe
- AdoMet
- S-(5'-Adenosyl)-L-methionine
Useful catalog search terms
- S-Adenosyl-L-methionine
- CAS 485-80-3
- PubChem CID 34756
Physicochemical data
| PubChem CID | 34756 |
|---|---|
| InChIKey | MEFKEPWMEQBLKI-AIRLBKTGSA-O |
| Functional role | Methyl-group donor and enzyme cofactor |
| InChI | InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 |
| SMILES | C[S+](CC[C@@H](C(=O)O)N)C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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