2'-FANA Nucleosides
2-Amino-6-methylthio-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine
Quick view. 2-Amino-6-methylthio-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine is a 2'-FANA nucleoside with CAS 109304-11-2. CAS 109304-11-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2-Amino-6-methylthio-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine is classified as 2'-fana nucleosides (Formula C11H14FN5O3S; molecular weight 315.32).
2-Amino-6-methylthio-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 2-Amino-6-methylthio-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-Deoxy-2'-fluoro-6-S-methyl-6-thio-ara-guanosine
- (2R,3R,4S,5R)-5-(2-amino-6-methylsulfanylpurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Useful catalog search terms
- CAS 109304-11-2
- 2'-FANA Nucleosides
Physicochemical data
| Systematic name | (2R,3R,4S,5R)-5-(2-amino-6-methylsulfanylpurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol |
|---|---|
| Sugar form | beta-D-arabinofuranosyl |
| Structural descriptors | 2'-fluoro; 6-methylthio; 2-amino |
| PubChem CID | 67740753 |
| InChI | InChI=1S/C11H14FN5O3S/c1-21-9-6-8(15-11(13)16-9)17(3-14-6)10-5(12)7(19)4(2-18)20-10/h3-5,7,10,18-19H,2H2,1H3,(H2,13,15,16)/t4-,5+,7-,10-/m1/s1 |
| InChIKey | SLPSXWQJKHAIQV-GQTRHBFLSA-N |
| SMILES | CSC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2-Amino-6-methylthio-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-9H-purine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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