Base-protected Nucleosides
2'-F-dG(DMF)
Quick view. N2-dimethylformamidine-protected 2'-fluoro-2'-deoxyguanosine with free 3' and 5' hydroxyl groups. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-F-dG(DMF) is classified as base-protected nucleosides.
2'-F-dG(DMF) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-F-dG(DMF), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N2-Dimethylformamidine-2'-fluoro-2'-deoxyguanosine
- 2'-Fluoro-dG(dmf)
Physicochemical data
| Nucleoside | 2'-Fluoro-2'-deoxyguanosine |
|---|---|
| Base protection | N2-dimethylformamidine (dmf) |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| CAS status | No public CAS assigned in the reviewed source set |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dG(DMF) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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