2'-FANA Nucleosides
2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine
Quick view. An unprotected N6-methyladenosine derivative with a 2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl sugar, CAS 126502-12-3. CAS 126502-12-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine is classified as 2'-fana nucleosides (Formula C11H14FN5O3; molecular weight 283.26).
2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N6-Methyl-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
- N6-Methyl-2'-fluoro-2'-deoxyarabinoadenosine
Useful catalog search terms
- CAS 126502-12-3
- MFCD30718510
Physicochemical data
| MDL number | MFCD30718510 |
|---|---|
| Systematic name | (2R,3R,4S,5R)-4-fluoro-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol |
| InChIKey | XVGMWRQRNLVRLF-WCGPTHBMSA-N |
| Isomeric SMILES | OC[C@H]1O[C@H]([C@H]([C@@H]1O)F)n1cnc2c1ncnc2NC |
| Sugar configuration | 2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl |
| Base modification | N6-methyladenine |
| PubChem CID | 14654362 |
| InChI | InChI=1S/C11H14FN5O3/c1-13-9-7-10(15-3-14-9)17(4-16-7)11-6(12)8(19)5(2-18)20-11/h3-6,8,11,18-19H,2H2,1H3,(H,13,14,15)/t5-,6+,8-,11-/m1/s1 |
| SMILES | CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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