Succinates
DMTr-2'-MOE-G(iBu)-3'-Succinate
Quick view. DMTr-2'-MOE-G(iBu)-3'-Succinate is a protected guanosine derivative bearing 5'-O-DMTr, 2'-O-(2-methoxyethyl), N2-isobutyryl, and 3'-O-succinate groups in the free-acid form. The reviewed identity corresponds to PubChem CID 168447238. CAS 2622236-64-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-MOE-G(iBu)-3'-Succinate is classified as protected 2'-o-moe guanosine 3'-o-succinate (Formula C42H47N5O12; molecular weight 813.80).
DMTr-2'-MOE-G(iBu)-3'-Succinate is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For DMTr-2'-MOE-G(iBu)-3'-Succinate, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine-3'-succinate
Useful catalog search terms
- CAS 2622236-64-8
- Succinates
Physicochemical data
| PubChem CID | 168447238 |
|---|---|
| InChIKey | CYESRKJDDOYPRE-NWKNMEOGSA-N |
| Structural features | 5'-O-DMTr; 2'-O-(2-methoxyethyl); N2-isobutyryl guanine; 3'-O-succinate; free carboxylic acid |
| InChI | InChI=1S/C42H47N5O12/c1-25(2)38(51)45-41-44-37-34(39(52)46-41)43-24-47(37)40-36(56-22-21-53-3)35(59-33(50)20-19-32(48)49)31(58-40)23-57-42(26-9-7-6-8-10-26,27-11-15-29(54-4)16-12-27)28-13-17-30(55-5)18-14-28/h6-18,24-25,31,35-36,40H,19-23H2,1-5H3,(H,48,49)(H2,44,45,46,51,52)/t31-,35-,36-,40-/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)CCC(=O)O)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-MOE-G(iBu)-3'-Succinate or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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OR-SUCC-0003DMTr-2'-F-dA(Bz)-3'-succinate, TEA salt
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OR-SUCC-0004DMTr-2'-F-dC(Ac)-3'-succinate, TEA salt
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OR-SUCC-0005DMTr-2'-F-dG(iBu)-3'-succinate, TEA salt
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Product-family literature
These publications provide peer-reviewed context for the Succinates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.