2'-O-Me Nucleosides
2'-O-Methyl-2,5'-anhydrouridine
Quick view. A stereodefined uridine derivative bearing a 2'-O-methyl group and a 2,5'-anhydro linkage, CAS 175471-64-4. CAS 175471-64-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methyl-2,5'-anhydrouridine is classified as 2'-o-me nucleosides (Formula C10H12N2O5; molecular weight 240.21).
2'-O-Methyl-2,5'-anhydrouridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Methyl-2,5'-anhydrouridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- [6R-(6alpha,7alpha,8alpha,9alpha)]-7,8,9,10-tetrahydro-8-hydroxy-7-methoxy-6,9-epoxy-2H,6H-pyrimido[2,1-b][1,3]oxazocin-2-one
Useful catalog search terms
- CAS 175471-64-4
- C10H12N2O5
Physicochemical data
| Sugar substitution | 2'-O-methyl |
|---|---|
| Anhydro linkage | 2,5'-anhydro |
| Free hydroxyl | 3'-OH |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-2,5'-anhydrouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.