Reverse Phosphoramidites
3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite
Quick view. A reverse-orientation N2-isobutyryl 2'-O-MOE guanosine phosphoramidite with 3'-O-DMTr and a 5'-CE phosphoramidite group for research-use oligonucleotide synthesis. CAS 725223-44-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite is classified as reverse phosphoramidites (Formula C47H60N7O10P; molecular weight 914.01).
3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite — Reverse-orientation 2'-O-MOE-rG(iBu) building block for research-use oligonucleotide synthesis.
For 3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- Rev 2'-O-MOE-G(iBu)-5'-amidite
- 2'-O-MOE-G(iBu) Reverse Phosphoramidite
- OR-RP-0022
- OR-2OMP-0082
Useful catalog search terms
- 725223-44-9
- PA096
Physicochemical data
| Nucleoside | N2-isobutyryl-2'-O-MOE guanosine |
|---|---|
| 3'-O group | DMTr |
| 5'-O group | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
| Orientation | Reverse 3'-O-DMTr / 5'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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