Protected Nucleosides
3'-O-TBDMS-2'-F-dU
Quick view. 2'-Fluoro-2'-deoxyuridine bearing a 3'-O-TBDMS group with a free 5'-hydroxyl group. CAS 1445379-59-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-TBDMS-2'-F-dU is classified as protected nucleosides (Formula C15H25FN2O5Si; molecular weight 360.46).
3'-O-TBDMS-2'-F-dU is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-O-TBDMS-2'-F-dU, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-fluoro-2'-deoxyuridine
- 2'-Deoxy-3'-O-TBDMS-2'-fluorouridine
Useful catalog search terms
- CAS 1445379-59-8
Physicochemical data
| Nucleoside | 2'-Fluoro-2'-deoxyuridine |
|---|---|
| Hydroxyl protection | 3'-O-TBDMS |
| Hydroxyl state | 5' hydroxyl group unprotected |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=CC(=O)NC2=O)CO |
| InChI | InChI=1S/C15H25FN2O5Si/c1-15(2,3)24(4,5)23-12-9(8-19)22-13(11(12)16)18-7-6-10(20)17-14(18)21/h6-7,9,11-13,19H,8H2,1-5H3,(H,17,20,21)/t9-,11-,12-,13-/m1/s1 |
| InChIKey | KKWGVZHEXOEALO-OJAKKHQRSA-N |
| PubChem CID | 122706669 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-O-TBDMS-2'-F-dU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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