Modified Nucleosides
4',5'-Didehydro-5'-deoxy-2'-O-methyluridine
Quick view. A modified uridine nucleoside with 4',5' unsaturation, 5'-deoxy substitution, and a 2'-O-methyl ether, CAS 1848223-48-2. CAS 1848223-48-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
4',5'-Didehydro-5'-deoxy-2'-O-methyluridine is classified as modified nucleosides (Formula C10H12N2O5; molecular weight 240.21).
4',5'-Didehydro-5'-deoxy-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 4',5'-Didehydro-5'-deoxy-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-Deoxy-4',5'-didehydro-2'-O-methyluridine
- Uridine, 4',5'-didehydro-5'-deoxy-2'-O-methyl-
Useful catalog search terms
- CAS 1848223-48-2
- C10H12N2O5
- AYTOADFYFHPUBK-IWSPIJDZSA-N
Physicochemical data
| Nucleobase | Uracil |
|---|---|
| Sugar unsaturation | 4',5'-Didehydro |
| Sugar modification | 5'-Deoxy; 2'-O-methyl |
| Stereochemistry | Three assigned sugar stereocenters |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 4',5'-Didehydro-5'-deoxy-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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