Ara Nucleosides
4-Chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Quick view. A protected 2'-fluoro-beta-D-arabino pyrrolo[2,3-d]pyrimidine intermediate bearing 3',5'-di-O-benzoyl and 4-chloro substitution. CAS 169516-55-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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![Chemical structure of 4-Chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine](/structures/6a9acd2eb831b61c.svg)
Product profile
4-Chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is classified as ara nucleosides (Formula C25H19ClFN3O5; molecular weight 495.89).
4-Chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine — Protected 2'-fluoro-beta-D-arabino pyrrolo[2,3-d]pyrimidine intermediate for structure-specific nucleoside synthesis research.
For 4-Chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- ((2R,3R,4S,5R)-3-(Benzoyloxy)-5-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate
Useful catalog search terms
- CAS 169516-55-6
- protected fluoro arabino pyrrolopyrimidine
Physicochemical data
| Sugar configuration | 2'-Deoxy-2'-fluoro-beta-D-arabinofuranosyl |
|---|---|
| Hydroxyl protection | 3',5'-Di-O-benzoyl |
| Heterocycle | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine |
| PubChem CID | 10480934 |
| InChI | InChI=1S/C25H19ClFN3O5/c26-21-17-11-12-30(22(17)29-14-28-21)23-19(27)20(35-25(32)16-9-5-2-6-10-16)18(34-23)13-33-24(31)15-7-3-1-4-8-15/h1-12,14,18-20,23H,13H2/t18-,19+,20-,23-/m1/s1 |
| InChIKey | GNUVHXHFIIZVRP-VLVHOKLOSA-N |
| SMILES | C1=CC=C(C=C1)C(=O)OC[C@@H]2[C@H]([C@@H]([C@@H](O2)N3C=CC4=C3N=CN=C4Cl)F)OC(=O)C5=CC=CC=C5 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 4-Chloro-7-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Ara Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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