DMTr-protected Nucleosides
5'-O-DMTr-3'-NH2-2'-O-Me-dU
Quick view. Uridine bearing a 5'-O-DMTr group, a 2'-O-methyl group and a direct 3'-amino substituent. CAS 182934-58-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-3'-NH2-2'-O-Me-dU is classified as dmtr-protected nucleosides (Formula C31H33N3O7; molecular weight 559.60).
5'-O-DMTr-3'-NH2-2'-O-Me-dU provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5'-O-DMTr-3'-NH2-2'-O-Me-dU, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-3'-amino-2'-O-methyluridine
- 5'-O-DMT-3'-NH2-2'-O-Me-U
Useful catalog search terms
- CAS 182934-58-3
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr; 2'-O-methyl |
| 3' substitution | Amino |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-3'-NH2-2'-O-Me-dU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.