2'-Fluoro Phosphoramidites
DMTr-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite
Quick view. A protected 2'-fluoro guanosine L-PSM phosphoramidite building block for research-use oligonucleotide synthesis. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite is classified as protected 2'-fluoro guanosine l-psm phosphoramidite (Formula C47H50FN6O10PS; molecular weight 940.98).
DMTr-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite — PSM phosphoramidites are described in patent literature as chiral-auxiliary reagents for research on chirally controlled internucleotidic linkages.
For DMTr-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite
Useful catalog search terms
- C47H50FN6O10PS
Physicochemical data
| Base protection | N2-isobutyryl (iBu) |
|---|---|
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| Sugar modification | 2'-fluoro |
| 3'-function | (L)-PSM phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-2FP-0003DMTr-2'-F-dC(Bz)-3'-(D)-DPSE-Phosphoramidite
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OR-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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OR-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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