Other Phosphoramidites
5'-O-DMTr-N1-methyl-2'-deoxypseudouridine 3'-CE phosphoramidite
Quick view. A protected N1-methyl-2'-deoxypseudouridine C-nucleoside 3'-CE phosphoramidite monomer for solid-phase oligonucleotide synthesis research. CAS 170933-43-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-N1-methyl-2'-deoxypseudouridine 3'-CE phosphoramidite is classified as other phosphoramidites (Formula C40H49N4O8P; molecular weight 744.83).
5'-O-DMTr-N1-methyl-2'-deoxypseudouridine 3'-CE phosphoramidite — Protected N1-methyl-2'-deoxypseudouridine C-nucleoside phosphoramidite monomer for solid-phase oligonucleotide synthesis research.
For 5'-O-DMTr-N1-methyl-2'-deoxypseudouridine 3'-CE phosphoramidite, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- N1-Me-dpU-CE-Phosphoramidite
- DNA N1-Methyl Pseudouridine amidite
Useful catalog search terms
- CAS 170933-43-4
- N1-methyl deoxypseudouridine phosphoramidite
Physicochemical data
| InChIKey | NZTPNOZYQYLBNQ-CHLLBEJBSA-N |
|---|---|
| Nucleoside | N1-Methyl-2'-deoxypseudouridine C-nucleoside |
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| 3' functionality | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| InChI | InChI=1S/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-36-24-35(34-25-43(5)39(46)42-38(34)45)51-37(36)26-49-40(29-12-9-8-10-13-29,30-14-18-32(47-6)19-15-30)31-16-20-33(48-7)21-17-31/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37-,53?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@@H](O[C@@H]1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)C5=CN(C(=O)NC5=O)C |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@@H](O[C@@H]1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)C5=CN(C(=O)NC5=O)C |
| PubChem CID | 178204462 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe 5'-O-DMTr-N1-methyl-2'-deoxypseudouridine 3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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