Protected Nucleosides
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine
Quick view. A guanosine derivative bearing N2-isobutyryl, 5'-O-dimethoxytrityl and 2'-O-propargyl groups, CAS 171486-53-6. CAS 171486-53-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine is classified as protected nucleosides (Formula C38H39N5O8; molecular weight 693.76).
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine
- 5'-O-DMT-2'-O-propargyl-N2-isobutyrylguanosine
Useful catalog search terms
- CAS 171486-53-6
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| 5' protection | dimethoxytrityl (DMTr) |
| 2'-O modification | propargyl |
| 3'-O state | free hydroxyl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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