2'-O-Me Nucleosides
N4-Methyl-2'-O-methylcytidine
Quick view. A cytidine nucleoside bearing N4-methyl and 2'-O-methyl substitutions, CAS 13048-95-8. CAS 13048-95-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N4-Methyl-2'-O-methylcytidine is classified as 2'-o-me nucleosides (Formula C11H17N3O5; molecular weight 271.27).
N4-Methyl-2'-O-methylcytidine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For N4-Methyl-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N4,O2'-Dimethylcytidine
- m4Cm
Useful catalog search terms
- N4-Methyl-2'-O-methyl-cytidine
- CAS 13048-95-8
Physicochemical data
| Base modification | N4-methyl |
|---|---|
| Sugar modification | 2'-O-methyl |
| InChI | InChI=1S/C11H17N3O5/c1-12-7-3-4-14(11(17)13-7)10-9(18-2)8(16)6(5-15)19-10/h3-4,6,8-10,15-16H,5H2,1-2H3,(H,12,13,17)/t6-,8-,9-,10-/m1/s1 |
| InChIKey | BNXGRQLXOMSOMV-PEBGCTIMSA-N |
| SMILES | CNC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N4-Methyl-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.