Protected Nucleosides
N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine
Quick view. An N4-benzoyl-protected 2',2'-difluoro-2'-deoxycytidine derivative, CAS 142816-70-4. CAS 142816-70-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine is classified as protected nucleosides (Formula C16H15F2N3O5; molecular weight 367.30).
N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine — An N4-benzoyl-protected 2',2'-difluoro-2'-deoxycytidine intermediate for research use in nucleoside synthesis.
For N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N-Benzoyl-2'-deoxy-2',2'-difluorocytidine
- 4-N-Benzoylgemcitabine
- N4-Bz-2',2'-diF-dC
- Cytidine, N-benzoyl-2'-deoxy-2',2'-difluoro-
Useful catalog search terms
- 142816-70-4
Physicochemical data
| Nucleoside | 2',2'-Difluoro-2'-deoxycytidine |
|---|---|
| Base protection | N4-Benzoyl |
| Hydroxyl state | Free 3'-OH and 5'-OH |
| Product form | Protected nucleoside (not a phosphoramidite or nucleotide) |
| PubChem CID | 11100665 |
| InChI | InChI=1S/C16H15F2N3O5/c17-16(18)12(23)10(8-22)26-14(16)21-7-6-11(20-15(21)25)19-13(24)9-4-2-1-3-5-9/h1-7,10,12,14,22-23H,8H2,(H,19,20,24,25)/t10-,12-,14-/m1/s1 |
| InChIKey | HSMDTRXWNNAGKY-MPKXVKKWSA-N |
| SMILES | C1=CC=C(C=C1)C(=O)NC2=NC(=O)N(C=C2)[C@H]3C([C@@H]([C@H](O3)CO)O)(F)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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