Modified Nucleosides
N6-Ethyl-2'-O-methyladenosine
Quick view. An adenosine building block bearing N6-ethyl and 2'-O-methyl modifications for structure-specific nucleoside and nucleotide research. CAS 157309-11-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-Ethyl-2'-O-methyladenosine is classified as modified nucleosides (Formula C13H19N5O4; molecular weight 309.32).
N6-Ethyl-2'-O-methyladenosine — N6-ethyl- and 2'-O-methyl-modified adenosine building block for structure-specific nucleoside and nucleotide research.
For N6-Ethyl-2'-O-methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- CAS 157309-11-0
- PubChem CID 57009522
Physicochemical data
| PubChem CID | 57009522 |
|---|---|
| InChIKey | KEZGDNKRYXLGKM-QYVSTXNMSA-N |
| IUPAC name | (2R,3R,4R,5R)-5-[6-(ethylamino)purin-9-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-ol |
| SMILES | CCNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
| Nucleobase modification | N6-ethyl |
| Sugar modification | 2'-O-methyl |
| InChI | InChI=1S/C13H19N5O4/c1-3-14-11-8-12(16-5-15-11)18(6-17-8)13-10(21-2)9(20)7(4-19)22-13/h5-7,9-10,13,19-20H,3-4H2,1-2H3,(H,14,15,16)/t7-,9-,10-,13-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6-Ethyl-2'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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