Intermediates
PC Biotin-PEG3-alkyne
Quick view. PC Biotin-PEG3-alkyne is a photocleavable biotin PEG alkyne linker intermediate identified by CAS 1869922-24-6. CAS 1869922-24-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
PC Biotin-PEG3-alkyne is classified as intermediates (Formula C35H52N6O12S; molecular weight 780.89).
PC Biotin-PEG3-alkyne — Reference use: photocleavable biotin linker studies involving alkyne-azide conjugation.
For PC Biotin-PEG3-alkyne, affinity tags can introduce steric effects; spacer length, label position and enzymatic incorporation efficiency should be verified.
Names and search terms
Confirmed or normalized name variants
- PrecisePEG AAD-5283
- AxisPharm AP11061
Useful catalog search terms
- CAS 1869922-24-6
- C35H52N6O12S
Physicochemical data
| Functional group | Alkyne |
|---|---|
| PubChem CID | 91757783 |
| InChIKey | HRHZIAGPIYYJMG-MJUSKHNJSA-N |
| InChI | InChI=1S/C35H52N6O12S/c1-4-11-38-35(45)53-24(2)25-21-28(48-3)29(22-27(25)41(46)47)52-14-7-10-32(43)37-13-16-50-18-20-51-19-17-49-15-12-36-31(42)9-6-5-8-30-33-26(23-54-30)39-34(44)40-33/h1,21-22,24,26,30,33H,5-20,23H2,2-3H3,(H,36,42)(H,37,43)(H,38,45)(H2,39,40,44)/t24?,26-,30-,33-/m0/s1 |
| SMILES | CC(C1=CC(=C(C=C1[N+](=O)[O-])OCCCC(=O)NCCOCCOCCOCCNC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3)OC)OC(=O)NCC#C |
| Canonical SMILES | CC(C1=CC(=C(C=C1[N+](=O)[O-])OCCCC(=O)NCCOCCOCCOCCNC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3)OC)OC(=O)NCC#C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Biotin labels provide strong downstream detection or enrichment options without radioactive labeling.
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Affinity tags can introduce steric effects; spacer length, label position and enzymatic incorporation efficiency should be verified.
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe PC Biotin-PEG3-alkyne or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.