Modified Nucleosides
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine
Quick view. 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is a C5-substituted modified deoxyuridine with CAS 115794-55-3. CAS 115794-55-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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![Chemical structure of 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine](/structures/5af95e1e7cd3f590.svg)
Product profile
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is classified as c5-substituted modified deoxyuridine (Formula C14H16F3N3O6; molecular weight 379.29).
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- TFA-AA-dU
- 5-TFA-aa-2'-dU
- TFA-AA-2'-deoxyuridine
- ChemicalBook CB92454305
Useful catalog search terms
- CAS 115794-55-3
Physicochemical data
| Systematic name | 2,2,2-Trifluoro-N-((E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)allyl)acetamide |
|---|---|
| Structural feature | Trifluoroacetyl-protected aminoallyl substituent with E geometry |
| PubChem CID | 10959831 |
| InChI | InChI=1S/C14H16F3N3O6/c15-14(16,17)12(24)18-3-1-2-7-5-20(13(25)19-11(7)23)10-4-8(22)9(6-21)26-10/h1-2,5,8-10,21-22H,3-4,6H2,(H,18,24)(H,19,23,25)/b2-1+/t8-,9+,10+/m0/s1 |
| InChIKey | MBPYSSRDTGXWJD-HFVMFMDWSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)/C=C/CNC(=O)C(F)(F)F)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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