2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-alpha-D-arabinouridine
Quick view. A 2'-deoxy-2'-fluoro arabino nucleoside with 4'-thio sugar-ring substitution and a 5-methyluracil base. CAS 294868-24-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-alpha-D-arabinouridine is classified as 2'-fana nucleosides (Formula C10H13FN2O4S; molecular weight 276.29 g/mol).
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-alpha-D-arabinouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-alpha-D-arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 294868-24-9
Physicochemical data
| PubChem CID | 12166363 |
|---|---|
| Systematic name | 1-[(2S,3S,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-methylpyrimidine-2,4-dione |
| Sugar modification | 2'-deoxy-2'-fluoro-arabino; 4'-thio |
| Base modification | 5-methyluracil |
| InChIKey | RCDAZGNPWLZONT-AYHNYZOXSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-alpha-D-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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