2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-5-methylarabinocytidine
Quick view. A stereodefined 2'-FANA cytidine bearing a 5-methyl nucleobase substitution, identified by CAS 78636-53-0. CAS 78636-53-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2'-fluoro-5-methylarabinocytidine is classified as 2'-fana nucleosides (Formula C10H14FN3O4; molecular weight 259.23).
2'-Deoxy-2'-fluoro-5-methylarabinocytidine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-Deoxy-2'-fluoro-5-methylarabinocytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-Fluoro-5-methylarabinofuranosylcytosine
Useful catalog search terms
- CAS 78636-53-0
- PubChem CID 514806
Physicochemical data
| Sugar modification | 2'-deoxy-2'-fluoro arabinofuranosyl |
|---|---|
| Nucleobase modification | cytosine C5 methyl |
| InChIKey | QZZJZXAWLQYJFK-JVZYCSMKSA-N |
| PubChem CID | 514806 |
| InChI | InChI=1S/C10H14FN3O4/c1-4-2-14(10(17)13-8(4)12)9-6(11)7(16)5(3-15)18-9/h2,5-7,9,15-16H,3H2,1H3,(H2,12,13,17)/t5-,6+,7-,9-/m1/s1 |
| SMILES | CC1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-methylarabinocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.