Modified Nucleotides
2'-O-Methyladenosine 5'-monophosphate
Quick view. The free-acid form of 2'-O-methyladenosine 5'-monophosphate for modified-nucleotide and nucleic-acid chemistry research. CAS 24121-00-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methyladenosine 5'-monophosphate is classified as modified nucleotides (Formula C11H16N5O7P; molecular weight 361.25).
2'-O-Methyladenosine 5'-monophosphate — 2'-O-methyl adenosine 5'-monophosphate building block for structure-specific modified-nucleotide and nucleic-acid chemistry research.
For 2'-O-Methyladenosine 5'-monophosphate, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Methyl-AMP
- 2'-O-Me-AMP
- 5'-Adenylic acid, 2'-O-methyl-
- 5'-Phosphono-O2'-methyladenosine
Useful catalog search terms
- CAS 24121-00-4
- PubChem CID 161605
Physicochemical data
| InChIKey | TVGFEBXIZUYVFR-IOSLPCCCSA-N |
|---|---|
| SMILES | CO[C@@H]1[C@H](O)[C@@H](COP(=O)(O)O)O[C@H]1n1cnc2c(N)ncnc21 |
| Sugar modification | 2'-O-methyl |
| Phosphate position | 5'-monophosphate |
| Chemical form | Free acid |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyladenosine 5'-monophosphate or its named chemical feature. Broader product-family guidance is maintained on the category page.
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