2'-O-MOE Nucleosides
4',5'-Didehydro-2'-O-(2-methoxyethyl)-5-methyluridine
Quick view. 5-Methyluridine derivative bearing a 2'-O-(2-methoxyethyl) group and a terminal-methylene 4',5'-unsaturated sugar moiety. CAS 2095417-31-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
4',5'-Didehydro-2'-O-(2-methoxyethyl)-5-methyluridine is classified as 2'-o-moe nucleosides (Formula C13H18N2O6; molecular weight 298.30 g/mol).
4',5'-Didehydro-2'-O-(2-methoxyethyl)-5-methyluridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 4',5'-Didehydro-2'-O-(2-methoxyethyl)-5-methyluridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- 2095417-31-3
Physicochemical data
| Nucleoside | 5-methyluridine |
|---|---|
| Sugar modification | 4',5'-didehydro terminal methylene |
| 2' modification | O-(2-methoxyethyl) |
| InChIKey | YGYCDYPJEBJBCU-CKYFFXLPSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 4',5'-Didehydro-2'-O-(2-methoxyethyl)-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.