2'-O-MOE Nucleosides
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine
Quick view. Uridine derivative bearing 5'-azido-5'-deoxy and 2'-O-(2-methoxyethyl) sugar modifications. CAS 2095417-60-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine is classified as 2'-o-moe nucleosides (Formula C12H17N5O6; molecular weight 327.30 g/mol).
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- 2095417-60-8
Physicochemical data
| Base scaffold | Uridine |
|---|---|
| Sugar modification | 2'-O-(2-methoxyethyl) |
| 5' modification | 5'-azido-5'-deoxy |
| InChIKey | AUWXNELCYLBZGW-QCNRFFRDSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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