2'-FANA Nucleosides
N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine
Quick view. An N6-benzoyl-protected adenosine derivative bearing a 2'-deoxy-2'-fluoro arabino sugar, CAS 144924-99-2. CAS 144924-99-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine is classified as 2'-fana nucleosides (Formula C17H16FN5O4; molecular weight 373.34).
N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine — An N6-benzoyl-protected 2'-FANA adenosine derivative for research use in modified nucleoside synthesis.
For N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-N6-Bz-2'-ara-dA
- Benzamide, N-[9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-yl]-
- TNU1100
Useful catalog search terms
- Benzamide N-[9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-yl]
- 144924-99-2
Physicochemical data
| Physical form | Solid |
|---|---|
| Base protection | N6-Benzoyladenine |
| Sugar configuration | 2'-Deoxy-2'-fluoro-beta-D-arabinofuranosyl |
| Hydroxyl state | Free 3' and 5' hydroxyls |
| PubChem CID | 53883372 |
| InChI | InChI=1S/C17H16FN5O4/c18-11-13(25)10(6-24)27-17(11)23-8-21-12-14(19-7-20-15(12)23)22-16(26)9-4-2-1-3-5-9/h1-5,7-8,10-11,13,17,24-25H,6H2,(H,19,20,22,26)/t10-,11+,13-,17-/m1/s1 |
| InChIKey | HLJZTLWDAQVZBU-WYFUGZQLSA-N |
| SMILES | C1=CC=C(C=C1)C(=O)NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@H]([C@@H]([C@H](O4)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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