2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine
Quick view. A beta-D-arabinouridine derivative bearing a 2'-fluoro substituent and a 5-hydroxymethyl group on the uracil base. CAS 94817-51-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine is classified as 2'-fana nucleosides (Formula C10H13FN2O6; molecular weight 276.22 g/mol).
2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine — 2'-Fluoro-5-hydroxymethyl arabinouridine building block for downstream modified-nucleoside and oligonucleotide chemistry.
For 2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-(hydroxymethyl)-
Useful catalog search terms
- 94817-51-3
- C10H13FN2O6
- QQGGRUHEDAEEQQ-JVZYCSMKSA-N
Physicochemical data
| SMILES | OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N(C(N2)=O)C=C(CO)C2=O)O1 |
|---|---|
| Nucleoside | Beta-D-arabinouridine |
| Sugar modification | 2'-Fluoro |
| Base modification | 5-Hydroxymethyl |
| InChIKey | QQGGRUHEDAEEQQ-JVZYCSMKSA-N |
| InChI | InChI=1S/C10H13FN2O6/c11-6-7(16)5(3-15)19-9(6)13-1-4(2-14)8(17)12-10(13)18/h1,5-7,9,14-16H,2-3H2,(H,12,17,18)/t5-,6+,7-,9-/m1/s1 |
| Canonical SMILES | OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N(C(N2)=O)C=C(CO)C2=O)O1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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