3'-O-TBDMS Phosphoramidites
5'-O-DMTr-3'-O-TBDMS-uridine-2'-CE phosphoramidite
Quick view. A protected uridine building block bearing 5'-O-DMTr and 3'-O-TBDMS groups with a 2'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 129451-77-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-3'-O-TBDMS-uridine-2'-CE phosphoramidite is classified as 3'-o-tbdms phosphoramidites (Formula C45H61N4O9PSi; molecular weight 861.05).
5'-O-DMTr-3'-O-TBDMS-uridine-2'-CE phosphoramidite — Identity-defined 3'-O-TBDMS uridine 2'-phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-3'-O-TBDMS-uridine-2'-CE phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-rU phosphoramidite
- 3'-TBDMS-rU phosphoramidite
- DMT-3'-O-TBDMS-U-2'-CE phosphoramidite
Useful catalog search terms
- CAS 129451-77-0
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| 5' protection | DMTr |
| 3' protection | TBDMS |
| 2'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| MDL number | MFCD00274112 |
| PubChem CID | 14376044 |
| InChIKey | UZVSHRLVIXPYEZ-ZMHKPELYSA-N |
| InChI | InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-41-40(58-60(10,11)44(5,6)7)38(56-42(41)48-28-26-39(50)47-43(48)51)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
Product-family literature
These publications provide peer-reviewed context for the 3'-O-TBDMS Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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