2'-FANA Nucleosides
N2-Isobutyryl-2'-fluoro-2'-deoxyarabinoguanosine
Quick view. A 2'-fluoro-2'-deoxyarabino guanosine nucleoside bearing N2-isobutyryl protection. CAS 308356-20-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-2'-fluoro-2'-deoxyarabinoguanosine is classified as n2-protected 2'-fana guanosine nucleoside (Formula C14H18FN5O5; molecular weight 355.32 g/mol).
N2-Isobutyryl-2'-fluoro-2'-deoxyarabinoguanosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For N2-Isobutyryl-2'-fluoro-2'-deoxyarabinoguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N2-iso-Butyroyl-2'-fluoro-2'-deoxyarabinoguanosine
Useful catalog search terms
- 308356-20-9
- SLHADUUWJSVYGQ-NDORMNELSA-N
Physicochemical data
| PubChem CID | 136395929 |
|---|---|
| IUPAC name | N-[9-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
| InChIKey | SLHADUUWJSVYGQ-NDORMNELSA-N |
| InChI | InChI=1S/C14H18FN5O5/c1-5(2)11(23)18-14-17-10-8(12(24)19-14)16-4-20(10)13-7(15)9(22)6(3-21)25-13/h4-7,9,13,21-22H,3H2,1-2H3,(H2,17,18,19,23,24)/t6-,7+,9-,13-/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N2-Isobutyryl-2'-fluoro-2'-deoxyarabinoguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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