DMTr-protected Nucleosides
3',5'-O-DMTr-2'-O-Me-rA(Bz)
Quick view. N6-Benzoyl-2'-O-methyladenosine bearing DMTr groups at both the 3'- and 5'-oxygen positions. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3',5'-O-DMTr-2'-O-Me-rA(Bz) is classified as dmtr-protected nucleosides.
3',5'-O-DMTr-2'-O-Me-rA(Bz) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 3',5'-O-DMTr-2'-O-Me-rA(Bz), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3',5'-O-DMT-2'-O-Me-rA(Bz)
Useful catalog search terms
- NS070-1
Physicochemical data
| Protection pattern | N6-benzoyl; 2'-O-methyl; 3'-O-DMTr; 5'-O-DMTr |
|---|---|
| CAS status | No public CAS Registry Number is listed for the reviewed product form. |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3',5'-O-DMTr-2'-O-Me-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.