Modified Nucleosides
5-(Methoxycarbonyl)methyl-2'-O-methyluridine
Quick view. A 2'-O-methyluridine bearing a 5-(methoxycarbonyl)methyl substituent, identified by CAS 60197-31-1. CAS 60197-31-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-(Methoxycarbonyl)methyl-2'-O-methyluridine is classified as modified nucleosides (Formula C13H18N2O8; molecular weight 330.29).
5-(Methoxycarbonyl)methyl-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-(Methoxycarbonyl)methyl-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Methyluridine 5-acetic acid methyl ester
- mcm5Um
Useful catalog search terms
- CAS 60197-31-1
Physicochemical data
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)CC(=O)OC)CO)O |
|---|---|
| PubChem CID | 14776494 |
| InChIKey | XOTXNXXJZCFUOA-UGKPPGOTSA-N |
| InChI | InChI=1S/C13H18N2O8/c1-21-8(17)3-6-4-15(13(20)14-11(6)19)12-10(22-2)9(18)7(5-16)23-12/h4,7,9-10,12,16,18H,3,5H2,1-2H3,(H,14,19,20)/t7-,9-,10-,12-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-(Methoxycarbonyl)methyl-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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