Modified Nucleosides
N1-Methyl-3'-O-methylguanosine
Quick view. A stereodefined guanosine nucleoside methylated at N1 and the ribose 3'-oxygen, identified by CAS 74466-66-3. CAS 74466-66-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N1-Methyl-3'-O-methylguanosine is classified as modified nucleosides (Formula C12H17N5O5; molecular weight 311.29).
N1-Methyl-3'-O-methylguanosine can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For N1-Methyl-3'-O-methylguanosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 1,3'-Dimethylguanosine
- Guanosine, 1-methyl-3'-O-methyl-
Useful catalog search terms
- CAS 74466-66-3
- PubChem CID 131884455
Physicochemical data
| Nucleobase modification | N1-methyl |
|---|---|
| Sugar modification | 3'-O-methyl |
| InChIKey | FKWCSDZDAGWXEN-IOSLPCCCSA-N |
| PubChem CID | 131884455 |
| InChI | InChI=1S/C12H17N5O5/c1-16-10(20)6-9(15-12(16)13)17(4-14-6)11-7(19)8(21-2)5(3-18)22-11/h4-5,7-8,11,18-19H,3H2,1-2H3,(H2,13,15)/t5-,7-,8-,11-/m1/s1 |
| SMILES | CN1C(=O)C2=C(N=C1N)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe N1-Methyl-3'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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