Modified Nucleosides
2',3'-Dideoxythymidine
Quick view. A stereodefined thymidine analogue lacking both the 2'- and 3'-hydroxyl groups, CAS 3416-05-5. CAS 3416-05-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3'-Dideoxythymidine is classified as modified nucleosides (Formula C10H14N2O4; molecular weight 226.23 g/mol).
2',3'-Dideoxythymidine for modified nucleoside chemistry and chemical identity research.
For 2',3'-Dideoxythymidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 3'-Deoxythymidine
- Dideoxythymidine
- ddT
Useful catalog search terms
- 3416-05-5
- PubChem CID 65119
- XKKCQTLDIPIRQD-JGVFFNPUSA-N
Physicochemical data
| PubChem CID | 65119 |
|---|---|
| IUPAC name | 1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| InChIKey | XKKCQTLDIPIRQD-JGVFFNPUSA-N |
| InChI | InChI=1S/C10H14N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h4,7-8,13H,2-3,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2CC[C@H](O2)CO |
| Stereochemistry | (2R,5S) |
| Sugar modification | 2',3'-dideoxy |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',3'-Dideoxythymidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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