2'-FANA Nucleosides
2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine
Quick view. An N6,N6-dimethyladenosine derivative bearing a 2'-deoxy-2'-fluoro arabino sugar, CAS 144924-81-2. CAS 144924-81-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine is classified as 2'-fana nucleosides (Formula C12H16FN5O3; molecular weight 297.29).
2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine — An N6,N6-dimethyl 2'-FANA adenosine derivative for research use in modified purine nucleoside synthesis.
For 2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N6,N6-Dimethyl-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine
- GL101913
- TNU0320
Useful catalog search terms
- 144924-81-2
Physicochemical data
| Physical form | Solid |
|---|---|
| Nucleobase | N6,N6-Dimethyladenine |
| Sugar configuration | 2'-Deoxy-2'-fluoro-beta-D-arabinofuranosyl |
| Hydroxyl state | Free 3' and 5' hydroxyls |
| PubChem CID | 168449420 |
| InChI | InChI=1S/C12H16FN5O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-7(13)9(20)6(3-19)21-12/h4-7,9,12,19-20H,3H2,1-2H3/t6-,7+,9-,12-/m1/s1 |
| InChIKey | VYOFGEWTSVZOGF-MCOZSMFQSA-N |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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