2'-FANA Nucleosides
2-Hydroxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine
Quick view. A 6-amino-2-oxo purine nucleoside with a 2'-fluoro-beta-D-arabino sugar, identified by CAS 899827-82-8. CAS 899827-82-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2-Hydroxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine is classified as 2'-fana nucleosides (Formula C10H12FN5O4; molecular weight 285.23).
2-Hydroxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine — 2'-FANA purine nucleoside building block and identity reference for further modified-nucleoside chemistry
For 2-Hydroxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 6-Amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-2H-purin-2-one
- Clofarabine Impurity 9
Useful catalog search terms
- CAS 899827-82-8
- 6-amino-2-oxo purine 2'-FANA nucleoside
- A938700
Physicochemical data
| Systematic identity | 6-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-2H-purin-2-one |
|---|---|
| SMILES | C1=NC2=C(NC(=O)N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N |
| Nucleobase | 6-Amino-2-oxo purine (2-hydroxy tautomer) |
| Sugar configuration | 2'-Deoxy-2'-fluoro-beta-D-arabino |
| Free hydroxyl groups | 3' and 5' |
| PubChem CID | 15788526 |
| InChIKey | SRUXNNJIKBFXNW-AYQXTPAHSA-N |
| InChI | InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(12)14-10(19)15-8(5)16/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4+,6-,9-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2-Hydroxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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