Modified Nucleosides
3',5'-Bis-O-(tert-butyldimethylsilyl)-4'-C-hydroxymethylthymidine
Quick view. A 4'-C-hydroxymethylthymidine derivative bearing 3'-O- and 5'-O-tert-butyldimethylsilyl protection, CAS 179178-45-1. CAS 179178-45-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3',5'-Bis-O-(tert-butyldimethylsilyl)-4'-C-hydroxymethylthymidine is classified as modified nucleosides (Formula C23H44N2O6Si2; molecular weight 500.78).
3',5'-Bis-O-(tert-butyldimethylsilyl)-4'-C-hydroxymethylthymidine is associated with cytosine-containing building blocks or substrates for C-position incorporation and analytical comparison.
For 3',5'-Bis-O-(tert-butyldimethylsilyl)-4'-C-hydroxymethylthymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3',5'-Bis-O-TBDMS-4'-C-hydroxymethylthymidine
- Thymidine, 3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-4'-C-(hydroxymethyl)-
Useful catalog search terms
- CAS 179178-45-1
- C23H44N2O6Si2
- ZRFLPQYOFGOZFC-YZZKKUAISA-N
Physicochemical data
| Nucleoside | Thymidine |
|---|---|
| Sugar modification | 4'-C-Hydroxymethyl |
| Protection pattern | 3'-O- and 5'-O-tert-butyldimethylsilyl |
| Stereochemistry | Assigned nucleoside configuration |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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