Halogenated Nucleosides
5-Fluoro-4'-C-methyluridine
Quick view. A uridine analog bearing fluorine at C5 of the base and a methyl group at sugar C4', identified by CAS 660845-69-2. CAS 660845-69-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Fluoro-4'-C-methyluridine is classified as halogenated nucleosides (Formula C10H13FN2O6; molecular weight 276.22).
5-Fluoro-4'-C-methyluridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Fluoro-4'-C-methyluridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 5-Fluoro-4'-C-methyl-uridine
- CAS 660845-69-2
Physicochemical data
| Base modification | 5-Fluoro |
|---|---|
| Sugar modification | 4'-C-methyl |
| Isomeric SMILES | O[C@H]1[C@@H](O[C@@](CO)(C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2 |
| PubChem CID | 510971 |
| InChIKey | MLJJNLSGOFMBET-TWOTXZKJSA-N |
| InChI | InChI=1S/C10H13FN2O6/c1-10(3-14)6(16)5(15)8(19-10)13-2-4(11)7(17)12-9(13)18/h2,5-6,8,14-16H,3H2,1H3,(H,12,17,18)/t5-,6+,8-,10-/m1/s1 |
| SMILES | C[C@]1([C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)F)O)O)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Fluoro-4'-C-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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