Halogenated Nucleosides
5-Iodo-2'-O-methylcytidine
Quick view. A cytidine analog bearing a 5-iodo base modification and a 2'-O-methyl sugar modification, identified by CAS 847650-69-5. CAS 847650-69-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Iodo-2'-O-methylcytidine is classified as halogenated nucleosides (Formula C10H14IN3O5; molecular weight 383.14).
5-Iodo-2'-O-methylcytidine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-Iodo-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- CAS 847650-69-5
- PubChem CID 68768358
Physicochemical data
| PubChem CID | 68768358 |
|---|---|
| InChIKey | JQWRBXTVVLSBBM-JXOAFFINSA-N |
| Nucleoside | cytidine |
| Base modification | 5-iodo |
| Sugar modification | 2'-O-methyl |
| Free hydroxyls | 3'-OH and 5'-OH |
| InChI | InChI=1S/C10H14IN3O5/c1-18-7-6(16)5(3-15)19-9(7)14-2-4(11)8(12)13-10(14)17/h2,5-7,9,15-16H,3H2,1H3,(H2,12,13,17)/t5-,6-,7-,9-/m1/s1 |
| SMILES | CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(I)c(=N)nc1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Iodo-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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