Halogenated Nucleosides
7-Deaza-2',3'-dideoxy-7-iodoadenosine
Quick view. 7-Deaza-2',3'-dideoxy-7-iodoadenosine is a 7-iodo-7-deazaadenosine nucleoside bearing a 2',3'-dideoxy sugar, with CAS 114748-70-8. CAS 114748-70-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
7-Deaza-2',3'-dideoxy-7-iodoadenosine is classified as 7-iodo-7-deaza-2',3'-dideoxyadenosine nucleoside (Formula C11H13IN4O2; molecular weight 360.15).
7-Deaza-2',3'-dideoxy-7-iodoadenosine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 7-Deaza-2',3'-dideoxy-7-iodoadenosine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 7-Iodo-2',3'-dideoxy-7-deazaadenosine
- 7-I-7-Deaza-ddA
- PubChem CID 14159244
Useful catalog search terms
- CAS 114748-70-8
Physicochemical data
| IUPAC name | [(2S,5R)-5-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)oxolan-2-yl]methanol |
|---|---|
| InChI | InChI=1S/C11H13IN4O2/c12-7-3-16(8-2-1-6(4-17)18-8)11-9(7)10(13)14-5-15-11/h3,5-6,8,17H,1-2,4H2,(H2,13,14,15)/t6-,8+/m0/s1 |
| InChIKey | OEZWDZXBBPSXGY-POYBYMJQSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C3=C(N=CN=C32)N)I |
| Structural feature | 7-deaza/7-iodo base with 2',3'-dideoxy sugar |
| PubChem CID | 14159244 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 7-Deaza-2',3'-dideoxy-7-iodoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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