Modified Nucleosides
N1,N2-Dimethyl-2'-O-methylguanosine
Quick view. Guanosine derivative methylated at N1, N2, and the sugar 2'-oxygen. CAS 2305416-05-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
N1,N2-Dimethyl-2'-O-methylguanosine is classified as modified nucleosides (Formula C13H19N5O5; molecular weight 325.32 g/mol).
N1,N2-Dimethyl-2'-O-methylguanosine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For N1,N2-Dimethyl-2'-O-methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2305416-05-9
Physicochemical data
| PubChem CID | 168448737 |
|---|---|
| Nucleoside | Guanosine |
| Substitution pattern | N1-methyl; N2-methyl; 2'-O-methyl |
| IUPAC name | 9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1-methyl-2-(methylamino)purin-6-one |
| InChIKey | WBFRVDBPHGTCFR-WOUKDFQISA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N1,N2-Dimethyl-2'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
OR-OP-0069S-Adenosyl-L-methionine (SAM)
Modified Nucleosides · CAS: 485-80-3
OR-MN-01875-(Carboxyhydroxymethyl)uridine
Modified Nucleosides · CAS: 934743-11-0
OR-MN-0719(R)-N6-(2,3-Dihydro-1H-inden-1-yl)adenosine
Modified Nucleosides · CAS: 96392-15-3
OR-MN-01972,2'-Cyclocytidine hydrochloride
Modified Nucleosides · CAS: 10212-25-6
OR-MN-0199N3-Allyluridine
Modified Nucleosides · CAS: 103951-13-9
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.